samfurori

Menene Nitric Oxide?

Nitric oxide iskar gas ne da sel masu shiga cikin kumburin da ke hade da rashin lafiyan ko eosinophilic asma.

Menene FeNO?

Gwajin Nitric Oxide (FeNO) mai juzu'i wata hanya ce ta auna adadin nitric oxide a cikin numfashin da aka fitar.Wannan gwajin zai iya taimakawa tare da gano cutar asma ta hanyar nuna matakin kumburi a cikin huhu.

Clinical Utility na FeNO

FeNO na iya ba da haɗin gwiwa mara ɓarna don gano farkon cutar asma tare da ATS da NICE suna ba da shawarar a matsayin wani ɓangare na jagororinsu na yanzu da algorithms bincike.

Gajartawa: ATS, American Thoracic Society;FeNO, nitric oxide na juzu'i da aka fitar;GINA, Ƙaddamar da Duniya don Asthma;ICS, inhaled corticosteroid;NICE, Cibiyar Kula da Lafiya da Ƙwararrun Kulawa ta ƙasa.

Jagororin ATS sun ayyana babban, matsakaici, da ƙananan matakan FeNO a cikin manya kamar> 50 ppb, 25 zuwa 50 ppb, da <25 ppb, bi da bi.Duk da yake a cikin yara, an kwatanta manyan, matsakaici, da ƙananan matakan FeNO a matsayin> 35 ppb, 20 zuwa 35 ppb, da <20 ppb (Table 1).ATS yana ba da shawarar yin amfani da FeNO don tallafawa ganewar asali na asma inda ake buƙatar shaidar haƙiƙa, musamman a cikin ganewar cutar kumburin eosinophilic.ATS ya bayyana cewa matakan FeNO masu girma (> 50 ppb a cikin manya da> 35 ppb a cikin yara), lokacin da aka fassara a cikin mahallin asibiti, yana nuna cewa kumburi na eosinophilic yana tare da amsawar corticosteroid a cikin marasa lafiya na alamun bayyanar cututtuka, yayin da ƙananan matakan (<25 ppb a cikin manya). da <20 ppb a cikin yara) ya sa wannan ba zai yiwu ba kuma ya kamata a fassara matakan matsakaici tare da taka tsantsan.

Jagororin NICE na yanzu, waɗanda ke amfani da ƙananan matakan yanke FeNO fiye da ATS (Table 1), suna ba da shawarar yin amfani da FeNO a matsayin wani ɓangare na aikin bincike inda ake yin la'akari da gano cutar asma a cikin manya ko kuma inda akwai rashin tabbas ga yara.An sake fassara matakan FeNO a cikin mahallin asibiti da ƙarin gwaji, kamar gwajin tsokanar ƙwayar cuta na iya taimaka wa ganewar asali ta hanyar nuna rashin amsawar iska.Jagororin GINA sun yarda da rawar FeNO a cikin gano kumburin eosinophilic a cikin asma amma a halin yanzu ba sa ganin rawar FeNO a cikin algorithms gano asma.Ƙimar Scottish Consensus ta bayyana yanke-offs bisa ga bayyanar steroid tare da kyawawan dabi'u na> 40 ppb a cikin marasa lafiya na steroid-naive da> 25 ppb ga marasa lafiya akan ICS.